| Reaction Details |
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 | Report a problem with these data |
| Target | Replicative DNA helicase |
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| Ligand | BDBM50400421 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_877478 (CHEMBL2183632) |
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| IC50 | >100000±n/a nM |
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| Citation |  Li, B; Pai, R; Di, M; Aiello, D; Barnes, MH; Butler, MM; Tashjian, TF; Peet, NP; Bowlin, TL; Moir, DT Coumarin-based inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicase: chemical optimization, biological evaluation, and antibacterial activities. J Med Chem55:10896-908 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Replicative DNA helicase |
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| Name: | Replicative DNA helicase |
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| Synonyms: | BAS5321 | GBAA_5717 | dnaB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50177.37 |
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| Organism: | Bacillus anthracis |
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| Description: | ChEMBL_877478 |
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| Residue: | 453 |
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| Sequence: | MSDVMADRTPPHNIEAEQAVLGAILIDQDALTSASELLVPDSFYRTKHQKIFEVMLGLSD
KGEPIDLVMMTSAMADQGLLEEVGGVSYLAELAEVVPTAANVEYYARIIAEKALLRRLIR
TATHIVSDGYEREDDVDGLLNEAEKKILEVSHQTNAKAFQNIKDVLVDAYDKIELLHNQK
GEVTGIPTGFTELDKMTAGFQRNDLIIVAARPSVGKTAFSLNIAQNVATKTDENVAIFSL
EMGADQLVMRMLCAEGNIDAQRLRTGSLTSDDWAKLTMAMGSLSNAGIYIDDTPGIKVNE
IRAKCRRLKQEQGLGMILIDYLQLIQGSGKSGENRQQEVSEISRTLKGIARELQVPVIAL
SQLSRGVESRQDKRPMMSDIRESGSIEQDADIVAFLYREDYYDRETENKNTIEIIIAKQR
NGPVGSVELAFVKEFNKFVNLERRFEDGHAPPA
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| BDBM50400421 |
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| n/a |
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| Name | BDBM50400421 |
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| Synonyms: | CHEMBL2178451 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H32N2O5 |
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| Mol. Mass. | 512.5962 |
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| SMILES | CC(=O)NCCNC(=O)CCc1c(C)c2ccc(OCc3ccc(cc3)-c3ccccc3)c(C)c2oc1=O |
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| Structure | 
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