| Reaction Details |
|---|
 | Report a problem with these data |
| Target | dTMP kinase |
|---|
| Ligand | BDBM50400464 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_877484 (CHEMBL2183638) |
|---|
| Ki | >1000000±n/a nM |
|---|
| Citation |  Cui, H; Carrero-Lérida, J; Silva, AP; Whittingham, JL; Brannigan, JA; Ruiz-Pérez, LM; Read, KD; Wilson, KS; González-Pacanowska, D; Gilbert, IH Synthesis and evaluation ofa-thymidine analogues as novel antimalarials. J Med Chem55:10948-57 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| dTMP kinase |
|---|
| Name: | dTMP kinase |
|---|
| Synonyms: | TMK | Thymidylate kinase, putative |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 24691.81 |
|---|
| Organism: | Plasmodium falciparum (isolate 3D7) |
|---|
| Description: | ChEMBL_877484 |
|---|
| Residue: | 210 |
|---|
| Sequence: | MTDDKKKGKFIVFEGLDRSGKSTQSKLLVEYLKNNNVEVKHLYFPNRETGIGQIISKYLK
MENSMSNETIHLLFSANRWEHMNEIKSLLLKGIWVVCDRYAYSGVAYSSGALNLNKTWCM
NPDQGLIKPDVVFYLNVPPNYAQNRSDYGEEIYEKVETQKKIYETYKHFAHEDYWINIDA
TRKIEDIHNDIVKEVTKIKVEPEEFNFLWS
|
|
|
|---|
| BDBM50400464 |
|---|
| n/a |
|---|
| Name | BDBM50400464 |
|---|
| Synonyms: | CHEMBL2178510 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H21N3O6S |
|---|
| Mol. Mass. | 431.462 |
|---|
| SMILES | Cc1cn([C@H]2C[C@H](O)[C@@H](CNS(=O)(=O)c3ccc4ccccc4c3)O2)c(=O)[nH]c1=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
