| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein-glutamine gamma-glutamyltransferase E |
|---|
| Ligand | BDBM50400619 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_880182 (CHEMBL2214884) |
|---|
| IC50 | >80000±n/a nM |
|---|
| Citation |  Wityak, J; Prime, ME; Brookfield, FA; Courtney, SM; Erfan, S; Johnsen, S; Johnson, PD; Li, M; Marston, RW; Reed, L; Vaidya, D; Schaertl, S; Pedret-Dunn, A; Beconi, M; Macdonald, D; Muņoz-Sanjuan, I; Dominguez, C SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington's Disease. ACS Med Chem Lett3:1024-1028 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein-glutamine gamma-glutamyltransferase E |
|---|
| Name: | Protein-glutamine gamma-glutamyltransferase E |
|---|
| Synonyms: | Protein-glutamine glutamyltransferase E | TGM3 | TGM3_HUMAN | Transglutaminase-3 (TG3) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 76625.90 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 693 |
|---|
| Sequence: | MAALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIMNKGLGSNERLEFIVST
GPYPSESAMTKAVFPLSNGSSGGWSAVLQASNGNTLTISISSPASAPIGRYTMALQIFSQ
GGISSVKLGTFILLFNPWLNVDSVFMGNHAEREEYVQEDAGIIFVGSTNRIGMIGWNFGQ
FEEDILSICLSILDRSLNFRRDAATDVASRNDPKYVGRVLSAMINSNDDNGVLAGNWSGT
YTGGRDPRSWNGSVEILKNWKKSGFSPVRYGQCWVFAGTLNTALRSLGIPSRVITNFNSA
HDTDRNLSVDVYYDPMGNPLDKGSDSVWNFHVWNEGWFVRSDLGPSYGGWQVLDATPQER
SQGVFQCGPASVIGVREGDVQLNFDMPFIFAEVNADRITWLYDNTTGKQWKNSVNSHTIG
RYISTKAVGSNARMDVTDKYKYPEGSDQERQVFQKALGKLKPNTPFAATSSMGLETEEQE
PSIIGKLKVAGMLAVGKEVNLVLLLKNLSRDTKTVTVNMTAWTIIYNGTLVHEVWKDSAT
MSLDPEEEAEHPIKISYAQYEKYLKSDNMIRITAVCKVPDESEVVVERDIILDNPTLTLE
VLNEARVRKPVNVQMLFSNPLDEPVRDCVLMVEGSGLLLGNLKIDVPTLGPKEGSRVRFD
ILPSRSGTKQLLADFSCNKFPAIKAMLSIDVAE
|
|
|
|---|
| BDBM50400619 |
|---|
| n/a |
|---|
| Name | BDBM50400619 |
|---|
| Synonyms: | CHEMBL2203476 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H33N3O6 |
|---|
| Mol. Mass. | 447.5246 |
|---|
| SMILES | CC(C)(C)OC(=O)CNC(=O)[C@H](CCCCNC(=O)C=C)NC(=O)OCc1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
