Reaction Details |
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Target | Protein-glutamine gamma-glutamyltransferase 2 |
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Ligand | BDBM50400619 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_880184 (CHEMBL2214886) |
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IC50 | 6200±n/a nM |
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Citation | Wityak, J; Prime, ME; Brookfield, FA; Courtney, SM; Erfan, S; Johnsen, S; Johnson, PD; Li, M; Marston, RW; Reed, L; Vaidya, D; Schaertl, S; Pedret-Dunn, A; Beconi, M; Macdonald, D; Muņoz-Sanjuan, I; Dominguez, C SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington's Disease. ACS Med Chem Lett3:1024-1028 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein-glutamine gamma-glutamyltransferase 2 |
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Name: | Protein-glutamine gamma-glutamyltransferase 2 |
Synonyms: | TG(C) | TGC | TGM2_MOUSE | TGase C | TGase-2 | Tgm2 | Tissue transglutaminase | Transglutaminase C | Transglutaminase-2 |
Type: | PROTEIN |
Mol. Mass.: | 77039.00 |
Organism: | Mus musculus |
Description: | ChEMBL_841041 |
Residue: | 686 |
Sequence: | MAEELLLERCDLEIQANGRDHHTADLCQEKLVLRRGQRFRLTLYFEGRGYEASVDSLTFG
AVTGPDPSEEAGTKARFSLSDNVEEGSWSASVLDQQDNVLSLQLCTPANAPIGLYRLSLE
ASTGYQGSSFVLGHFILLYNAWCPADDVYLDSEEERREYVLTQQGFIYQGSVKFIKSVPW
NFGQFEDGILDTCLMLLDMNPKFLKNRSRDCSRRSSPIYVGRVVSAMVNCNDDQGVLLGR
WDNNYGDGISPMAWIGSVDILRRWKEHGCQQVKYGQCWVFAAVACTVLRCLGIPTRVVTN
YNSAHDQNSNLLIEYFRNEFGELESNKSEMIWNFHCWVESWMTRPDLQPGYEGWQAIDPT
PQEKSEGTYCCGPVSVRAIKEGDLSTKYDAPFVFAEVNADVVDWIRQEDGSVLKSINRSL
VVGQKISTKSVGRDDREDITHTYKYPEGSPEEREVFTKANHLNKLAEKEETGVAMRIRVG
DSMSMGNDFDVFAHIGNDTSETRECRLLLCARTVSYNGVLGPECGTEDINLTLDPYSENS
IPLRILYEKYSGCLTESNLIKVRGLLIEPAANSYLLAERDLYLENPEIKIRVLGEPKQNR
KLVAEVSLKNPLSDPLYDCIFTVEGAGLTKEQKSVEVSDPVPAGDLVKARVDLFPTDIGL
HKLVVNFQCDKLKSVKGYRNVIIGPA
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BDBM50400619 |
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n/a |
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Name | BDBM50400619 |
Synonyms: | CHEMBL2203476 |
Type | Small organic molecule |
Emp. Form. | C23H33N3O6 |
Mol. Mass. | 447.5246 |
SMILES | CC(C)(C)OC(=O)CNC(=O)[C@H](CCCCNC(=O)C=C)NC(=O)OCc1ccccc1 |r| |
Structure |
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