| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase 33 |
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| Ligand | BDBM50400670 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_880288 (CHEMBL2216290) |
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| IC50 | 1600±n/a nM |
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| Citation |  Weïwer, M; Spoonamore, J; Wei, J; Guichard, B; Ross, NT; Masson, K; Silkworth, W; Dandapani, S; Palmer, M; Scherer, CA; Stern, AM; Schreiber, SL; Munoz, B A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett3:1034-1038 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase 33 |
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| Name: | Serine/threonine-protein kinase 33 |
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| Synonyms: | STK33 | STK33_HUMAN | Serine/threonine-protein kinase 33 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57833.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_23943882 |
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| Residue: | 514 |
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| Sequence: | MADSGLDKKSTKCPDCSSASQKDVLCVCSSKTRVPPVLVVEMSQTSSIGSAESLISLERK
KEKNINRDITSRKDLPSRTSNVERKASQQQWGRGNFTEGKVPHIRIENGAAIEEIYTFGR
ILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIHLEQ
VFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLK
LENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDY
SQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDCAKSVLKQ
LMKVDPAHRITAKELLDNQWLTGNKLSSVRPTNVLEMMKEWKNNPESVEENTTEEKNKPS
TEEKLKSYQPWGNVPDANYTSDEEEEKQSTAYEKQFPATSKDNFDMCSSSFTSSKLLPAE
IKGEMEKTPVTPSQGTATKYPAKSGALSRTKKKL
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| BDBM50400670 |
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| n/a |
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| Name | BDBM50400670 |
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| Synonyms: | CHEMBL2204233 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H11F2N3O2S |
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| Mol. Mass. | 383.371 |
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| SMILES | Fc1cc2nc(-c3ccccc3NC(=O)c3cccs3)c(=O)[nH]c2cc1F |
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| Structure | 
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