| Reaction Details |
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 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase SETMAR |
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| Ligand | BDBM50400779 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_879134 (CHEMBL2209105) |
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| IC50 | >100000±n/a nM |
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| Citation |  Verma, SK; Tian, X; LaFrance, LV; Duquenne, C; Suarez, DP; Newlander, KA; Romeril, SP; Burgess, JL; Grant, SW; Brackley, JA; Graves, AP; Scherzer, DA; Shu, A; Thompson, C; Ott, HM; Aller, GS; Machutta, CA; Diaz, E; Jiang, Y; Johnson, NW; Knight, SD; Kruger, RG; McCabe, MT; Dhanak, D; Tummino, PJ; Creasy, CL; Miller, WH Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett3:1091-1096 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone-lysine N-methyltransferase SETMAR |
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| Name: | Histone-lysine N-methyltransferase SETMAR |
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| Synonyms: | Histone-lysine N-methyltransferase | HsMar1 | Mariner transposase Hsmar1 | Metnase | SET domain and mariner transposase fusion gene-containing protein | SETMAR | SETMR_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78041.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_879134 |
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| Residue: | 684 |
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| Sequence: | MFAEAAKTTRPCGMAEFKEKPEAPTEQLDVACGQENLPVGAWPPGAAPAPFQYTPDHVVG
PGADIDPTQITFPGCICVKTPCLPGTCSCLRHGENYDDNSCLRDIGSGGKYAEPVFECNV
LCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQR
RIHLQTKSDSNYIIAIREHVYNGQVMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSM
VPKLALFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSCTAFLPF
DSSLYCPVEKSNISCGNEKEPSMCGSAPSVFPSCKRLTLETMKMMLDKKQIRAIFLFEFK
MGRKAAETTRNINNAFGPGTANERTVQWWFKKFCKGDESLEDEERSGRPSEVDNDQLRAI
IEADPLTTTREVAEELNVNHSTVVRHLKQIGKVKKLDKWVPHELTENQKNRRFEVSSSLI
LRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQEEAPKHFPKPILHPKKVMVTIWWSAA
GLIHYSFLNPGETITSEKYAQEIDEMNQKLQRLQLALVNRKGPILLHDNARPHVAQPTLQ
KLNELGYEVLPHPPYSPDLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQEFVESQSTDF
YATGINQLISRWQKCVDCNGSYFD
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| BDBM50400779 |
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| n/a |
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| Name | BDBM50400779 |
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| Synonyms: | CHEMBL2204998 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H35N7O2 |
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| Mol. Mass. | 513.6339 |
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| SMILES | CC(C)n1ncc2c(cc(cc12)-c1ccc(nc1)N1CCN(C)CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O |
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| Structure | 
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