| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone-arginine methyltransferase CARM1 |
|---|
| Ligand | BDBM50400781 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_879137 (CHEMBL2209108) |
|---|
| IC50 | 116000±n/a nM |
|---|
| Citation |  Verma, SK; Tian, X; LaFrance, LV; Duquenne, C; Suarez, DP; Newlander, KA; Romeril, SP; Burgess, JL; Grant, SW; Brackley, JA; Graves, AP; Scherzer, DA; Shu, A; Thompson, C; Ott, HM; Aller, GS; Machutta, CA; Diaz, E; Jiang, Y; Johnson, NW; Knight, SD; Kruger, RG; McCabe, MT; Dhanak, D; Tummino, PJ; Creasy, CL; Miller, WH Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett3:1091-1096 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone-arginine methyltransferase CARM1 |
|---|
| Name: | Histone-arginine methyltransferase CARM1 |
|---|
| Synonyms: | CARM1 | CARM1_HUMAN | Coactivator-associated arginine methyltransferase 1 | Coactivator-associated arginine methyltransferase 1 (CARM1) | PRMT4 | Protein arginine N-methyltransferase 4 | Protein arginine methyltransferase 4 (PRMT4) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 65855.47 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q86X55 |
|---|
| Residue: | 608 |
|---|
| Sequence: | MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEV
RAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSF
YNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNH
TDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPG
KVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDE
QLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFL
EAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRC
LFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTT
PSPPPGSHYTSPSENMWNTGSTYNLSSGMAVAGMPTAYDLSSVIASGSSVGHNNLIPLAN
TGIVNHTHSRMGSIMSTGIVQGSSGAQGSGGGSTSAHYAVNSQFTMGGPAISMASPMSIP
TNTMHYGS
|
|
|
|---|
| BDBM50400781 |
|---|
| n/a |
|---|
| Name | BDBM50400781 |
|---|
| Synonyms: | CHEMBL2204997 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H39N7O2 |
|---|
| Mol. Mass. | 541.6871 |
|---|
| SMILES | CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccc(nc1)N1CCN(C)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
