| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50036051 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_879292 (CHEMBL2208690) |
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| Ki | 25±n/a nM |
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| Citation |  Meanwell, NA Synopsis of some recent tactical application of bioisosteres in drug design. J Med Chem54:2529-91 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50036051 |
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| n/a |
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| Name | BDBM50036051 |
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| Synonyms: | ((S)-1-{(S)-2-[(S)-1-(Benzothiazole-2-carbonyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid benzyl ester | CHEMBL353441 | benzyl (S)-1-((S)-2-(((S)-1-(benzo[d]thiazol-2-yl)-3-methyl-1-oxobutan-2-yl)carbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate |
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| Type | Small organic molecule |
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| Emp. Form. | C30H36N4O5S |
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| Mol. Mass. | 564.696 |
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| SMILES | CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)c1nc2ccccc2s1 |
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| Structure | 
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