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TargetTranslocator protein
LigandBDBM50266889
Substrate/Competitorn/a
Meas. Tech.ChEMBL_879961 (CHEMBL2212410)
Ki 0.6±n/a nM
Citation Kumata, KYui, JHatori, AFujinaga, MYanamoto, KYamasaki, TKawamura, KWakizaka, HNengaki, NYoshida, YOgawa, MFukumura, TZhang, MR Synthesis and evaluation of novel carbon-11 labeled oxopurine analogues for positron emission tomography imaging of translocator protein (18 kDa) in peripheral organs. J Med Chem54:6040-9 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Translocator protein
Name:Translocator protein
Synonyms:Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:Mitochondrion membrane protein
Mol. Mass.:18945.84
Organism:Rattus norvegicus (rat)
Description:Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50266889
n/a
NameBDBM50266889
Synonyms:CHEMBL513922 | N-benzyl-N-ethyl-2-(7-methyl-8-oxo-2-phenyl-7H-purin-9(8H)-yl)acetamide
TypeSmall organic molecule
Emp. Form.C23H23N5O2
Mol. Mass.401.461
SMILESCCN(Cc1ccccc1)C(=O)Cn1c2nc(ncc2n(C)c1=O)-c1ccccc1
Structure
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