Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetThyroid hormone receptor beta
LigandBDBM50115668
Substrate/Competitorn/a
Meas. Tech.ChEMBL_883195 (CHEMBL2212121)
Kd 0.2±n/a nM
Citation Joharapurkar, AADhote, VVJain, MR Selective thyromimetics using receptor and tissue selectivity approaches: prospects for dyslipidemia. J Med Chem55:5649-75 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thyroid hormone receptor beta
Name:Thyroid hormone receptor beta
Synonyms:ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta
Type:Receptor
Mol. Mass.:52793.62
Organism:Homo sapiens (Human)
Description:Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1.
Residue:461
Sequence:
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50115668
n/a
NameBDBM50115668
Synonyms:3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxyacetic acid | CHEMBL107400 | GC-1 | US10322118, Entry 7 | US10544075, Compound GC-1 | [4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phenoxy]-acetic acid | [4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phenoxy]-acetic acid(GC-1) | {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid
TypeSmall organic molecule
Emp. Form.C20H24O4
Mol. Mass.328.4022
SMILESCC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)ccc1O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: