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TargetG protein-coupled receptor 44
LigandBDBM50401108
Substrate/Competitorn/a
Meas. Tech.ChEMBL_884446
IC50 2±n/a nM
Citation Kaila NHuang AMoretto AFollows BJanz KLowe MThomason JMansour TSHubeau CPage KMorgan PFish SXu XWilliams CSaiah E Diazine indole acetic acids as potent, selective, and orally bioavailable antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases. J Med Chem 55:5088-109 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
G protein-coupled receptor 44
Name:G protein-coupled receptor 44
Synonyms:CD_antigen=CD294 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | G-protein coupled receptor 44 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:Enzyme
Mol. Mass.:43295.45
Organism:Homo sapiens (Human)
Description:Q9Y5Y4
Residue:395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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BDBM50401108
n/a
NameBDBM50401108
Synonyms:CHEMBL2205148
TypeSmall organic molecule
Emp. Form.C27H21Cl2N3O4
Mol. Mass.522.379
SMILESCc1c(-c2nn(CCOc3ccc(Cl)cc3)c(=O)c3ccccc23)c2cc(Cl)ccc2n1CC(O)=O |(7.71,-8.01,;6.17,-8.01,;5.26,-6.75,;6.03,-5.43,;7.57,-5.44,;8.35,-4.11,;9.89,-4.11,;10.65,-5.45,;12.19,-5.46,;12.96,-6.8,;12.18,-8.12,;12.94,-9.46,;14.48,-9.46,;15.25,-10.8,;15.26,-8.13,;14.49,-6.79,;7.58,-2.77,;8.36,-1.44,;6.04,-2.76,;5.27,-1.43,;3.73,-1.43,;2.96,-2.77,;3.73,-4.1,;5.27,-4.1,;3.78,-7.23,;2.45,-6.47,;1.12,-7.24,;-.22,-6.47,;1.12,-8.79,;2.45,-9.56,;3.78,-8.79,;5.26,-9.26,;5.73,-10.73,;4.7,-11.87,;3.19,-11.56,;5.18,-13.34,)|
Structure
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