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TargetActivin receptor type-2B
LigandBDBM50401152
Substrate/Competitorn/a
Meas. Tech.ChEMBL_880955 (CHEMBL2216367)
IC50<10000±n/a nM
Citation Sunose, MBell, KEllard, KBergamini, GNeubauer, GWerner, TRamsden, N Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease. Bioorg Med Chem Lett22:4613-8 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Activin receptor type-2B
Name:Activin receptor type-2B
Synonyms:ACVR2B | AVR2B_HUMAN | Activin receptor type-2B
Type:Enzyme Catalytic Domain
Mol. Mass.:57713.76
Organism:Homo sapiens (Human)
Description:gi_116734708
Residue:512
Sequence:
MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY
ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG
GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP
PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK
HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY
LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG
TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ
HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL
IRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
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  Blast E-value cutoff:
BDBM50401152
n/a
NameBDBM50401152
Synonyms:CHEMBL2205766
TypeSmall organic molecule
Emp. Form.C15H18N6O2S
Mol. Mass.346.407
SMILESCC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Structure
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