| Reaction Details |
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 | Report a problem with these data |
| Target | Heat shock protein HSP 90-alpha |
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| Ligand | BDBM20800 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_883814 (CHEMBL2212191) |
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| IC50 | 5.1±n/a nM |
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| Citation |  Shi, J; Van de Water, R; Hong, K; Lamer, RB; Weichert, KW; Sandoval, CM; Kasibhatla, SR; Boehm, MF; Chao, J; Lundgren, K; Timple, N; Lough, R; Ibanez, G; Boykin, C; Burrows, FJ; Kehry, MR; Yun, TJ; Harning, EK; Ambrose, C; Thompson, J; Bixler, SA; Dunah, A; Snodgrass-Belt, P; Arndt, J; Enyedy, IJ; Li, P; Hong, VS; McKenzie, A; Biamonte, MA EC144 is a potent inhibitor of the heat shock protein 90. J Med Chem55:7786-95 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Heat shock protein HSP 90-alpha |
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| Name: | Heat shock protein HSP 90-alpha |
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| Synonyms: | HS90A_HUMAN | HSP 86 | HSP86 | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat Shock Protein 90 (Hsp90) | Heat shock 86 kDa | Heat shock protein HSP 90 (HSP90) | Heat shock protein HSP 90-alpha (HSP90) | Heat shock protein HSP 90-alpha (HSP90A) | LAP-2 | LPS-associated protein 2 | Lipopolysaccharide-associated protein 2 | Renal carcinoma antigen NY-REN-38 | heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2 |
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| Type: | Molecular Chaperone |
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| Mol. Mass.: | 84623.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07900 |
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| Residue: | 732 |
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| Sequence: | MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIR
YESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFME
ALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPM
GRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKED
KEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRN
PDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNN
IKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKC
LELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDY
CTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKT
LVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIV
TSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVK
DLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLE
GDDDTSRMEEVD
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| BDBM20800 |
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| n/a |
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| Name | BDBM20800 |
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| Synonyms: | 2-amino-6-halopurine analogue, 20 | 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine | CHEMBL467399 | hsp90_107 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H15ClN6O |
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| Mol. Mass. | 318.762 |
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| SMILES | COc1c(C)cnc(Cn2cnc3c(Cl)nc(N)nc23)c1C |
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| Structure | 
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