Reaction Details |
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Target | Heat shock protein 75 kDa, mitochondrial |
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Ligand | BDBM50401333 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_883816 (CHEMBL2212642) |
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Ki | 255±n/a nM |
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Citation | Shi, J; Van de Water, R; Hong, K; Lamer, RB; Weichert, KW; Sandoval, CM; Kasibhatla, SR; Boehm, MF; Chao, J; Lundgren, K; Timple, N; Lough, R; Ibanez, G; Boykin, C; Burrows, FJ; Kehry, MR; Yun, TJ; Harning, EK; Ambrose, C; Thompson, J; Bixler, SA; Dunah, A; Snodgrass-Belt, P; Arndt, J; Enyedy, IJ; Li, P; Hong, VS; McKenzie, A; Biamonte, MA EC144 is a potent inhibitor of the heat shock protein 90. J Med Chem55:7786-95 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Heat shock protein 75 kDa, mitochondrial |
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Name: | Heat shock protein 75 kDa, mitochondrial |
Synonyms: | HSP75 | TRAP1 | TRAP1_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 80120.13 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1478164 |
Residue: | 704 |
Sequence: | MARELRALLLWGRRLRPLLRAPALAAVPGGKPILCPRRTTAQLGPRRNPAWSLQAGRLFS
TQTAEDKEEPLHSIISSTESVQGSTSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNA
SDALEKLRHKLVSDGQALPEMEIHLQTNAEKGTITIQDTGIGMTQEELVSNLGTIARSGS
KAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLSDGSGVFE
IAEASGVRTGTKIIIHLKSDCKEFSSEARVRDVVTKYSNFVSFPLYLNGRRMNTLQAIWM
MDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIFYVPDMKPSMFDVSRELG
SSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQ
RLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIAKLLRYESSALPSGQL
TSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDTEVLFCFEQFDELTLLHLR
EFDKKKLISVETDIVVDHYKEEKFEDRSPAAECLSEKETEELMAWMRNVLGSRVTNVKVT
LRLDTHPAMVTVLEMGAARHFLRMQQLAKTQEERAQLLQPTLEINPRHALIKKLNQLRAS
EPGLAQLLVDQIYENAMIAAGLVDDPRAMVGRLNELLVKALERH
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BDBM50401333 |
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n/a |
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Name | BDBM50401333 |
Synonyms: | CHEMBL1230584 |
Type | Small organic molecule |
Emp. Form. | C21H24ClN5O2 |
Mol. Mass. | 413.901 |
SMILES | COc1c(C)cnc(Cn2cc(C#CCC(C)(C)O)c3c(Cl)nc(N)nc23)c1C |
Structure |
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