| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 1 |
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| Ligand | BDBM50401617 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_887293 (CHEMBL2216272) |
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| IC50 | 10000±n/a nM |
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| Citation |  Lainchbury, M; Matthews, TP; McHardy, T; Boxall, KJ; Walton, MI; Eve, PD; Hayes, A; Valenti, MR; de Haven Brandon, AK; Box, G; Aherne, GW; Reader, JC; Raynaud, FI; Eccles, SA; Garrett, MD; Collins, I Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors. J Med Chem55:10229-40 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 1 |
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| Name: | Cyclin-dependent kinase 1 |
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| Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 34101.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06493 |
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| Residue: | 297 |
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| Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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| BDBM50401617 |
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| n/a |
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| Name | BDBM50401617 |
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| Synonyms: | CHEMBL2204592 | US9403797, PAPC-A-02 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25N9O |
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| Mol. Mass. | 407.4722 |
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| SMILES | CNc1cc(Nc2cnc(C#N)c(O[C@H](C)CN(C)C)n2)ncc1-c1cnn(C)c1 |r| |
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| Structure | 
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