| Reaction Details |
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 | Report a problem with these data |
| Target | Peptidyl-glycine alpha-amidating monooxygenase |
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| Ligand | BDBM50401749 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_885021 (CHEMBL2211745) |
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| IC50 | 2000±n/a nM |
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| Citation |  Morris, KM; Cao, F; Onagi, H; Altamore, TM; Gamble, AB; Easton, CJ Prohormone-substrate peptide sequence recognition by peptidylglycinea-amidating monooxygenase and its reflection in increased glycolate inhibitor potency. Bioorg Med Chem Lett22:7015-8 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peptidyl-glycine alpha-amidating monooxygenase |
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| Name: | Peptidyl-glycine alpha-amidating monooxygenase |
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| Synonyms: | AMD_HUMAN | PAL | PAM | PHM | Peptidyl-alpha-hydroxyglycine alpha-amidating lyase | Peptidylamidoglycolate lyase | Peptidylglycine alpha-hydroxylating monooxygenase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 108328.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_885021 |
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| Residue: | 973 |
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| Sequence: | MAGRVPSLLVLLVFPSSCLAFRSPLSVFKRFKETTRPFSNECLGTTRPVVPIDSSDFALD
IRMPGVTPKQSDTYFCMSMRIPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWF
CDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNNKD
CSGVSLHLTRLPQPLIAGMYLMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRVHTHH
LGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATH
IGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHE
HHKETEYKDKIPLLQQPKREEEEVLDQGDFYSLLSKLLGEREDVVHVHKYNPTEKAESES
DLVAEIANVVQKKDLGRSDAREGAEHERGNAILVRDRIHKFHRLVSTLRPPESRVFSLQQ
PPPGEGTWEPEHTGDFHMEEALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSF
DSKFVYQQIGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALH
QVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPGTGAIYVSDGYCNSRIVQFS
PSGKFITQWGEESSGSSPLPGQFTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVR
EIKHSSFGRNVFAISYIPGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRKHFD
MPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQEIKEAEAVVETKMEN
KPTSSELQKMQEKQKLIKEPGSGVPVVLITTLLVIPVVVLLAIAIFIRWKKSRAFGDSEH
KLETSSGRVLGRFRGKGSGGLNLGNFFASRKGYSRKGFDRLSTEGSDQEKEDDGSESEEE
YSAPLPALAPSSS
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| BDBM50401749 |
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| n/a |
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| Name | BDBM50401749 |
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| Synonyms: | CHEMBL2207130 |
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| Type | Small organic molecule |
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| Emp. Form. | C52H73N11O15S2 |
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| Mol. Mass. | 1156.331 |
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| SMILES | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC(O)=O |r| |
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| Structure | 
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