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TargetCathepsin S
LigandBDBM50401769
Substrate/Competitorn/a
Meas. Tech.ChEMBL_885155 (CHEMBL2213246)
IC50 17±n/a nM
Citation Moss, NXiong, ZBurke, MCogan, DGao, DAHaverty, KHeim-Riether, AHickey, ERNagaraja, RNetherton, MO'Shea, KRamsden, PSchwartz, RShih, DTWard, YYoung, EZhang, Q Exploration of cathepsin S inhibitors characterized by a triazole P1-P2 amide replacement. Bioorg Med Chem Lett22:7189-93 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin S
Name:Cathepsin S
Synonyms:CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:Protein
Mol. Mass.:37507.38
Organism:Homo sapiens (Human)
Description:P25774
Residue:331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50401769
n/a
NameBDBM50401769
Synonyms:CHEMBL2207559
TypeSmall organic molecule
Emp. Form.C21H37N5O3
Mol. Mass.407.5502
SMILESCCC(C)(C)CC[C@H](NC(=O)N1CCOCC1)C(=O)NC1(CCN(C)CC1)C#N |r|
Structure
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