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TargetSigma non-opioid intracellular receptor 1
LigandBDBM50401859
Substrate/Competitorn/a
Meas. Tech.ChEMBL_886105 (CHEMBL2210027)
IC50 36.1±n/a nM
Citation Riganas, SPapanastasiou, IFoscolos, GBTsotinis, ASerin, GMirjolet, JFDimas, KKourafalos, VNEleutheriades, AMoutsos, VIKhan, HGeorgakopoulou, SZaniou, APrassa, MTheodoropoulou, MMantelas, APondiki, SVamvakides, A New adamantane phenylalkylamines withs-receptor binding affinity and anticancer activity, associated with putative antagonism of neuropathic pain. J Med Chem55:10241-61 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sigma non-opioid intracellular receptor 1
Name:Sigma non-opioid intracellular receptor 1
Synonyms:Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:Enzyme Catalytic Domain
Mol. Mass.:25124.85
Organism:Homo sapiens (Human)
Description:Q99720
Residue:223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50401859
n/a
NameBDBM50401859
Synonyms:CHEMBL2204677
TypeSmall organic molecule
Emp. Form.C37H46N2
Mol. Mass.518.7745
SMILESC(CN1CCN(Cc2ccccc2)CC1)Cc1ccc(cc1)C(c1ccccc1)C12CC3CC(CC(C3)C1)C2 |TLB:22:29:32.31.36:34,THB:22:29:32:36.35.34,37:29:32:36.35.34,37:35:32:38.30.29,30:31:34:38.29.37,30:29:32.31.36:34|
Structure
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