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TargetHistamine H4 receptor
LigandBDBM50401946
Substrate/Competitorn/a
Meas. Tech.ChEMBL_886475
Ki>10000±n/a nM
Citation Löber SHübner HBuschauer ASanna FArgiolas AMelis MRGmeiner P Novel azulene derivatives for the treatment of erectile dysfunction. Bioorg Med Chem Lett 22:7151-4 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H4 receptor
Name:Histamine H4 receptor
Synonyms:AXOR35 | G-protein coupled receptor 105 | GPRv53 | HH4R | HISTAMINE H4 | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44517.02
Organism:Homo sapiens (Human)
Description:Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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  Blast E-value cutoff:
BDBM50401946
n/a
NameBDBM50401946
Synonyms:CHEMBL2207639
TypeSmall organic molecule
Emp. Form.C27H33N3O2
Mol. Mass.431.5698
SMILESCOc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc23)CC1
Structure
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