| Reaction Details |
|---|
 | Report a problem with these data |
| Target | MAP kinase-activated protein kinase 3 |
|---|
| Ligand | BDBM50402020 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_886739 (CHEMBL2210053) |
|---|
| Ki | >9200±n/a nM |
|---|
| Citation |  Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors. Bioorg Med Chem Lett22:7615-22 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| MAP kinase-activated protein kinase 3 |
|---|
| Name: | MAP kinase-activated protein kinase 3 |
|---|
| Synonyms: | 3pK | Chromosome 3p kinase | MAP kinase-activated protein kinase 3 (MAPKAP-K3) | MAPK-Activated Protein Kinase 3 (MK3) | MAPK-activated protein kinase 3 | MAPK3_HUMAN | MAPKAP kinase 3 | MAPKAPK-3 | MAPKAPK3 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 42991.57 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant MAPKAPK3 was phosphorylated by incubation with active p38alpha before assays. |
|---|
| Residue: | 382 |
|---|
| Sequence: | MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLE
CFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMEC
MEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKD
AVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFP
PFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMN
HPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNR
LLNKRRKKQAGSSSASQGCNNQ
|
|
|
|---|
| BDBM50402020 |
|---|
| n/a |
|---|
| Name | BDBM50402020 |
|---|
| Synonyms: | CHEMBL2205426 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H22N6O2 |
|---|
| Mol. Mass. | 414.4598 |
|---|
| SMILES | CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccncc3)n2)c(=O)c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
