| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 alpha |
|---|
| Ligand | BDBM50402020 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_886811 (CHEMBL2210502) |
|---|
| Ki | 21±n/a nM |
|---|
| Citation |  Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors. Bioorg Med Chem Lett22:7615-22 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glycogen synthase kinase-3 alpha |
|---|
| Name: | Glycogen synthase kinase-3 alpha |
|---|
| Synonyms: | GSK-3 alpha | GSK3A | GSK3A_HUMAN | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3alpha) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 50991.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P49840 |
|---|
| Residue: | 483 |
|---|
| Sequence: | MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV
GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP
PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT
NSS
|
|
|
|---|
| BDBM50402020 |
|---|
| n/a |
|---|
| Name | BDBM50402020 |
|---|
| Synonyms: | CHEMBL2205426 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H22N6O2 |
|---|
| Mol. Mass. | 414.4598 |
|---|
| SMILES | CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccncc3)n2)c(=O)c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
