Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetLeukotriene A-4 hydrolase
LigandBDBM50402384
Substrate/Competitorn/a
Meas. Tech.ChEMBL_886318 (CHEMBL2212808)
IC50 3±n/a nM
Citation Tanis, VMBacani, GMBlevitt, JMChrovian, CCCrawford, SDe Leon, AFourie, AMGomez, LGrice, CAHerman, KKearney, AMLandry-Bayle, AMLee-Dutra, ANelson, JRiley, JPSantillán, AWiener, JJXue, XYoung, AL Azabenzthiazole inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem Lett22:7504-11 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Leukotriene A-4 hydrolase
Name:Leukotriene A-4 hydrolase
Synonyms:LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:Hydrolase; metalloprotease
Mol. Mass.:69280.41
Organism:Homo sapiens (Human)
Description:Human recombinant LTA4H.
Residue:611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50402384
n/a
NameBDBM50402384
Synonyms:CHEMBL2207749
TypeSmall organic molecule
Emp. Form.C21H22N4O2S
Mol. Mass.394.49
SMILESCC(=O)N1CC2CN(Cc3ccc(Oc4nc5ncccc5s4)cc3)CC2C1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: