| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Leukotriene A-4 hydrolase |
|---|
| Ligand | BDBM50402392 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_886318 (CHEMBL2212808) |
|---|
| IC50 | 4±n/a nM |
|---|
| Citation |  Tanis, VM; Bacani, GM; Blevitt, JM; Chrovian, CC; Crawford, S; De Leon, A; Fourie, AM; Gomez, L; Grice, CA; Herman, K; Kearney, AM; Landry-Bayle, AM; Lee-Dutra, A; Nelson, J; Riley, JP; Santillán, A; Wiener, JJ; Xue, X; Young, AL Azabenzthiazole inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem Lett22:7504-11 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Leukotriene A-4 hydrolase |
|---|
| Name: | Leukotriene A-4 hydrolase |
|---|
| Synonyms: | LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase |
|---|
| Type: | Hydrolase; metalloprotease |
|---|
| Mol. Mass.: | 69280.41 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human recombinant LTA4H. |
|---|
| Residue: | 611 |
|---|
| Sequence: | MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
|
|
|
|---|
| BDBM50402392 |
|---|
| n/a |
|---|
| Name | BDBM50402392 |
|---|
| Synonyms: | CHEMBL2207741 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H26N4O3S |
|---|
| Mol. Mass. | 438.543 |
|---|
| SMILES | CC(=O)NC1CC2CCC(C1)N2CCOc1ccc(Oc2nc3ncccc3s2)cc1 |TLB:3:4:11:7.8| |
|---|
| Structure | 
|
|---|
Search and Browse
