| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Microtubule-associated protein tau |
|---|
| Ligand | BDBM50129793 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_886329 (CHEMBL2212819) |
|---|
| IC50 | 3255±n/a nM |
|---|
| Citation |  Gu, J; Anumala, UR; Lo Monte, F; Kramer, T; Heyny von Haußen, R; Hölzer, J; Goetschy-Meyer, V; Mall, G; Hilger, I; Czech, C; Schmidt, B 2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer's disease. Bioorg Med Chem Lett22:7667-71 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Microtubule-associated protein tau |
|---|
| Name: | Microtubule-associated protein tau |
|---|
| Synonyms: | MAPT | MAPTL | MTBT1 | Microtubule-associated protein tau | Neurofibrillary tangle protein | PHF-tau | Paired helical filament-tau | TAU | TAU_HUMAN | Tau Protein |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 78928.63 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P10636 |
|---|
| Residue: | 758 |
|---|
| Sequence: | MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPG
SETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG
HVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEG
GRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPA
QDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLE
FTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPA
AAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSS
DPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQK
GQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREP
KKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLD
LSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEK
LDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDT
SPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
|
|
|
|---|
| BDBM50129793 |
|---|
| n/a |
|---|
| Name | BDBM50129793 |
|---|
| Synonyms: | 2-(4''-methylaminophenyl)-6-hydroxybenzothiazole | 2-(4-(methylamino)phenyl)benzo[d]thiazol-6-ol | 2-(4-Methylamino-phenyl)-benzothiazol-6-ol | 4-methylamino-phenyl)-benzothiazol-6-ol | 6-Hydroxy-2-(4''-N-methylaminophenyl)-1,3-benzothiazole | CHEMBL1788111 | CHEMBL93124 | N-methyl-2-(4''-methylaminophenyl)-6-hydroxybenzothiazole | N-methyl-[11C]2-(40-methylaminophenyl)-6-hydroxy benzothiazole | [3H]2-(4-(methylamino)phenyl)benzo[d]thiazol-6-ol |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H12N2OS |
|---|
| Mol. Mass. | 256.323 |
|---|
| SMILES | CNc1ccc(cc1)-c1nc2ccc(O)cc2s1 |
|---|
| Structure | 
|
|---|
Search and Browse
