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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucocorticoid receptor | ||
| Ligand | BDBM50402480 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_886649 (CHEMBL2216234) | ||
| Ki | 19±n/a nM | ||
| Citation |  Hunt, HJ; Ray, NC; Hynd, G; Sutton, J; Sajad, M; O'Connor, E; Ahmed, S; Lockey, P; Daly, S; Buckley, G; Clark, RD; Roe, R; Blasey, C; Belanoff, J Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat. Bioorg Med Chem Lett22:7376-80 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucocorticoid receptor | |||
| Name: | Glucocorticoid receptor | ||
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85656.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04150 | ||
| Residue: | 777 | ||
| Sequence: |
| ||
| BDBM50402480 | |||
| n/a | |||
| Name | BDBM50402480 | ||
| Synonyms: | CHEMBL2204061 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H28N2O2 | ||
| Mol. Mass. | 388.502 | ||
| SMILES | Cc1cccc(Cc2c([nH]c(=O)n(C)c2=O)[C@@H]2CC[C@@H](CC2)c2ccccc2)c1 |r,wU:16.16,19.23,(29.26,-4.19,;27.93,-4.95,;26.58,-4.17,;25.24,-4.93,;25.24,-6.47,;26.57,-7.25,;26.57,-8.81,;25.23,-9.6,;25.23,-11.15,;23.89,-11.92,;22.56,-11.15,;21.21,-11.94,;22.56,-9.61,;21.23,-8.83,;23.91,-8.83,;23.91,-7.29,;26.55,-11.92,;26.55,-13.46,;27.86,-14.24,;29.2,-13.48,;29.2,-11.94,;27.87,-11.15,;30.53,-14.26,;31.85,-13.49,;33.18,-14.27,;33.18,-15.81,;31.84,-16.57,;30.53,-15.8,;27.93,-6.5,)| | ||
| Structure | 
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