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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucocorticoid receptor | ||
| Ligand | BDBM50402494 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_886649 (CHEMBL2216234) | ||
| Ki | 5±n/a nM | ||
| Citation |  Hunt, HJ; Ray, NC; Hynd, G; Sutton, J; Sajad, M; O'Connor, E; Ahmed, S; Lockey, P; Daly, S; Buckley, G; Clark, RD; Roe, R; Blasey, C; Belanoff, J Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat. Bioorg Med Chem Lett22:7376-80 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucocorticoid receptor | |||
| Name: | Glucocorticoid receptor | ||
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85656.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04150 | ||
| Residue: | 777 | ||
| Sequence: |
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| BDBM50402494 | |||
| n/a | |||
| Name | BDBM50402494 | ||
| Synonyms: | CHEMBL2204047 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H22Cl2N2O2 | ||
| Mol. Mass. | 429.339 | ||
| SMILES | Clc1cccc(Cc2c([nH]c(=O)[nH]c2=O)[C@@H]2CC[C@@H](CC2)c2ccccc2)c1Cl |r,wU:15.15,18.22,(47.9,-44.62,;46.57,-45.39,;45.23,-44.61,;43.88,-45.36,;43.88,-46.9,;45.21,-47.69,;45.21,-49.25,;43.88,-50.03,;43.88,-51.59,;42.53,-52.35,;41.2,-51.59,;39.85,-52.38,;41.2,-50.04,;42.55,-49.27,;42.55,-47.73,;45.19,-52.36,;45.19,-53.9,;46.5,-54.67,;47.84,-53.91,;47.84,-52.37,;46.52,-51.59,;49.17,-54.69,;50.5,-53.93,;51.82,-54.7,;51.82,-56.25,;50.48,-57.01,;49.17,-56.23,;46.57,-46.93,;47.9,-47.71,)| | ||
| Structure | 
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