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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucocorticoid receptor | ||
| Ligand | BDBM50402501 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_886649 (CHEMBL2216234) | ||
| Ki | 3±n/a nM | ||
| Citation |  Hunt, HJ; Ray, NC; Hynd, G; Sutton, J; Sajad, M; O'Connor, E; Ahmed, S; Lockey, P; Daly, S; Buckley, G; Clark, RD; Roe, R; Blasey, C; Belanoff, J Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat. Bioorg Med Chem Lett22:7376-80 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucocorticoid receptor | |||
| Name: | Glucocorticoid receptor | ||
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85656.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04150 | ||
| Residue: | 777 | ||
| Sequence: |
| ||
| BDBM50402501 | |||
| n/a | |||
| Name | BDBM50402501 | ||
| Synonyms: | CHEMBL2204040 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H26N2O2 | ||
| Mol. Mass. | 374.4754 | ||
| SMILES | Cc1cccc(Cc2c([nH]c(=O)[nH]c2=O)[C@@H]2CC[C@@H](CC2)c2ccccc2)c1 |r,wU:15.15,18.22,(55.79,-2.75,;54.45,-3.51,;53.11,-2.73,;51.76,-3.49,;51.76,-5.03,;53.09,-5.81,;53.09,-7.38,;51.76,-8.16,;51.76,-9.71,;50.42,-10.48,;49.09,-9.71,;47.74,-10.51,;49.09,-8.17,;50.44,-7.39,;50.44,-5.85,;53.08,-10.49,;53.08,-12.03,;54.39,-12.8,;55.73,-12.04,;55.73,-10.5,;54.4,-9.72,;57.05,-12.82,;58.38,-12.06,;59.7,-12.83,;59.7,-14.38,;58.36,-15.14,;57.05,-14.36,;54.45,-5.06,)| | ||
| Structure | 
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