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TargetMitogen-activated protein kinase 9
LigandBDBM50402847
Substrate/Competitorn/a
Meas. Tech.ChEMBL_884763
IC50>20000±n/a nM
Citation Gong LTan YCBoice GAbbot SMcCaleb KIyer PZuo FDal Porto JWong BJin SChang ATran PHsieh GNiu LShao AReuter DLukacs CMUrsula Kammlott RKuglstatter AGoldstein D Discovery of a novel series of 4-quinolone JNK inhibitors. Bioorg Med Chem Lett 22:7381-7 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 9
Name:JNK2/JNK3
Synonyms:JNK-55 | JNK2/JNK3 | Mitogen-Activated Protein Kinase 9 (JNK2) | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2)
Type:Enzyme
Mol. Mass.:48131.49
Organism:Homo sapiens (Human)
Description:JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:424
Sequence:
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ
LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK
MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV
MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL
EGCR
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  Blast E-value cutoff:
BDBM50402847
n/a
NameBDBM50402847
Synonyms:CHEMBL2204102
TypeSmall organic molecule
Emp. Form.C16H14N2O2
Mol. Mass.266.2946
SMILESCCn1c(=O)n(-c2ccccc2)c2ccccc2c1=O
Structure
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