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TargetMitogen-activated protein kinase 8
LigandBDBM50402828
Substrate/Competitorn/a
Meas. Tech.ChEMBL_884764 (CHEMBL2216094)
IC50 65±n/a nM
Citation Gong, LTan, YCBoice, GAbbot, SMcCaleb, KIyer, PZuo, FDal Porto, JWong, BJin, SChang, ATran, PHsieh, GNiu, LShao, AReuter, DLukacs, CMUrsula Kammlott, RKuglstatter, AGoldstein, D Discovery of a novel series of 4-quinolone JNK inhibitors. Bioorg Med Chem Lett22:7381-7 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 8
Name:Mitogen-activated protein kinase 8
Synonyms:JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2)
Type:Enzyme
Mol. Mass.:48297.57
Organism:Homo sapiens (Human)
Description:JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:427
Sequence:
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50402828
n/a
NameBDBM50402828
Synonyms:CHEMBL2204095
TypeSmall organic molecule
Emp. Form.C23H24FN3O5S
Mol. Mass.473.517
SMILESCOC(=O)c1c(CN2CCN(CC2)S(C)(=O)=O)c(=O)c2ccc(F)cc2n1-c1ccccc1
Structure
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