| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 1 |
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| Ligand | BDBM50392982 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_884742 (CHEMBL2215623) |
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| Kd | >10000±n/a nM |
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| Citation |  Gong, L; Tan, YC; Boice, G; Abbot, S; McCaleb, K; Iyer, P; Zuo, F; Dal Porto, J; Wong, B; Jin, S; Chang, A; Tran, P; Hsieh, G; Niu, L; Shao, A; Reuter, D; Lukacs, CM; Ursula Kammlott, R; Kuglstatter, A; Goldstein, D Discovery of a novel series of 4-quinolone JNK inhibitors. Bioorg Med Chem Lett22:7381-7 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-1 receptor-associated kinase 1 |
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| Name: | Interleukin-1 receptor-associated kinase 1 |
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| Synonyms: | IRAK | IRAK-1 | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 76536.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51617 |
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| Residue: | 712 |
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| Sequence: | MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE
RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS
IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK
PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR
LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL
HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG
LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG
QRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDP
RPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPP
SPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALR
SWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQI
IINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
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| BDBM50392982 |
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| n/a |
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| Name | BDBM50392982 |
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| Synonyms: | CHEMBL2152382 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H23ClN2O5 |
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| Mol. Mass. | 490.935 |
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| SMILES | COC(=O)c1c(Cc2ccc(cc2)C(=O)NCCO)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 |
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| Structure | 
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