| Reaction Details |
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 | Report a problem with these data |
| Target | Cannabinoid receptor 1 |
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| Ligand | BDBM50402859 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_885143 (CHEMBL2213234) |
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| Ki | >30000±n/a nM |
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| Citation |  Thur, Y; Bhalerao, A; Munshi, Z; Pansare, N; Mann, K; Hanauer, G; Kley, HP; Nappe, S; Weiss-Haljiti, C; Ostermann, C; Zitt, C; Schaefer, M; Mondal, D; Ali Siddiki, A; Armugam, V; Gudaghe, V; Gupta, M; Rayudu, P; Dautzenberg, FM; Das Sarma, K Structure-activity relationships of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists and their analgesic action. Bioorg Med Chem Lett22:7314-21 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cannabinoid receptor 1 |
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| Name: | Cannabinoid receptor 1 |
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| Synonyms: | Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_RAT | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cnr1 | Skr6 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 52856.55 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P20272 |
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| Residue: | 473 |
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| Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAI
AVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHV
FHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCL
MWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILW
KAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPL
LAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTA
QPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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| BDBM50402859 |
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| n/a |
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| Name | BDBM50402859 |
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| Synonyms: | CHEMBL2205591 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15F5N2O3S |
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| Mol. Mass. | 446.391 |
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| SMILES | FC(F)(F)c1ccccc1C(=O)Nc1sc2COCCc2c1C(=O)N1CC(F)(F)C1 |
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| Structure | 
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