| Reaction Details |
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 | Report a problem with these data |
| Target | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase |
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| Ligand | BDBM50168988 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_885341 (CHEMBL2215204) |
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| Ki | 16810±n/a nM |
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| Citation |  Moorthy, NS; Brás, NF; Ramos, MJ; Fernandes, PA Virtual screening and QSAR study of some pyrrolidine derivatives asa-mannosidase inhibitors for binding feature analysis. Bioorg Med Chem20:6945-59 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase |
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| Name: | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase |
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| Synonyms: | MA1B1_HUMAN | MAN1B1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 79590.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_885341 |
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| Residue: | 699 |
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| Sequence: | MAACEGRRSGALGSSQSDFLTPPVGGAPWAVATTVVMYPPPPPPPHRDFISVTLSFGENY
DNSKSWRRRSCWRKWKQLSRLQRNMILFLLAFLLFCGLLFYINLADHWKALAFRLEEEQK
MRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDG
TQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQ
GTPVHLNYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWI
LGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGN
RLMPAFRTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEA
VEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQE
TQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVYHG
LPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPET
VESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFF
LGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPIWTPA
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| BDBM50168988 |
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| n/a |
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| Name | BDBM50168988 |
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| Synonyms: | (2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO}METHYL)PYRROLIDINE-3,4-DIOL | CHEMBL425723 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H20N2O3 |
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| Mol. Mass. | 252.3095 |
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| SMILES | OC[C@H](NC[C@H]1NC[C@H](O)[C@@H]1O)c1ccccc1 |r| |
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| Structure | 
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