Reaction Details |
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Target | Protein-tyrosine kinase 2-beta |
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Ligand | BDBM50402995 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_885500 (CHEMBL2209552) |
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IC50 | 1350±n/a nM |
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Citation | Bhattacharya, SK; Aspnes, GE; Bagley, SW; Boehm, M; Brosius, AD; Buckbinder, L; Chang, JS; Dibrino, J; Eng, H; Frederick, KS; Griffith, DA; Griffor, MC; Guimarães, CR; Guzman-Perez, A; Han, S; Kalgutkar, AS; Klug-McLeod, J; Garcia-Irizarry, C; Li, J; Lippa, B; Price, DA; Southers, JA; Walker, DP; Wei, L; Xiao, J; Zawistoski, MP; Zhao, X Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors. Bioorg Med Chem Lett22:7523-9 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein-tyrosine kinase 2-beta |
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Name: | Protein-tyrosine kinase 2-beta |
Synonyms: | FAK2 | FAK2_HUMAN | PTK2B | PTK2B protein tyrosine kinase 2 beta | PTK2B protein tyrosine kinase 2 beta (PTK2B) | PYK2 | Protein tyrosine kinase 2 beta | RAFTK |
Type: | Protein |
Mol. Mass.: | 115868.80 |
Organism: | Homo sapiens (Human) |
Description: | Q14289 |
Residue: | 1009 |
Sequence: | MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK
CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC
LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC
LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS
LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA
EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG
SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI
AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN
LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL
ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR
RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR
CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP
KYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMR
EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP
LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ
LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA
QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE
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BDBM50402995 |
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n/a |
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Name | BDBM50402995 |
Synonyms: | CHEMBL2207436 |
Type | Small organic molecule |
Emp. Form. | C22H24N8O2 |
Mol. Mass. | 432.4784 |
SMILES | Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1cc(n[nH]1)-c1ccc(=O)[nH]n1)C(C)(C)C |
Structure |
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