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TargetProtein-tyrosine kinase 2-beta
LigandBDBM50402997
Substrate/Competitorn/a
Meas. Tech.ChEMBL_885500 (CHEMBL2209552)
IC50 398±n/a nM
Citation Bhattacharya, SKAspnes, GEBagley, SWBoehm, MBrosius, ADBuckbinder, LChang, JSDibrino, JEng, HFrederick, KSGriffith, DAGriffor, MCGuimarães, CRGuzman-Perez, AHan, SKalgutkar, ASKlug-McLeod, JGarcia-Irizarry, CLi, JLippa, BPrice, DASouthers, JAWalker, DPWei, LXiao, JZawistoski, MPZhao, X Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors. Bioorg Med Chem Lett22:7523-9 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein-tyrosine kinase 2-beta
Name:Protein-tyrosine kinase 2-beta
Synonyms:FAK2 | FAK2_HUMAN | PTK2B | PTK2B protein tyrosine kinase 2 beta | PTK2B protein tyrosine kinase 2 beta (PTK2B) | PYK2 | Protein tyrosine kinase 2 beta | RAFTK
Type:Protein
Mol. Mass.:115868.80
Organism:Homo sapiens (Human)
Description:Q14289
Residue:1009
Sequence:
MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK
CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC
LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC
LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS
LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA
EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG
SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI
AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN
LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL
ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR
RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR
CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP
KYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMR
EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP
LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ
LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA
QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50402997
n/a
NameBDBM50402997
Synonyms:CHEMBL2207429
TypeSmall organic molecule
Emp. Form.C32H35N7O2
Mol. Mass.549.666
SMILESCN(CCc1ccccn1)C(=O)c1cc2cccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c2[nH]1
Structure
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