| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-tyrosine kinase 2-beta |
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| Ligand | BDBM50318872 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_885497 (CHEMBL2209549) |
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| IC50 | 190±n/a nM |
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| Citation |  Bhattacharya, SK; Aspnes, GE; Bagley, SW; Boehm, M; Brosius, AD; Buckbinder, L; Chang, JS; Dibrino, J; Eng, H; Frederick, KS; Griffith, DA; Griffor, MC; Guimarães, CR; Guzman-Perez, A; Han, S; Kalgutkar, AS; Klug-McLeod, J; Garcia-Irizarry, C; Li, J; Lippa, B; Price, DA; Southers, JA; Walker, DP; Wei, L; Xiao, J; Zawistoski, MP; Zhao, X Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors. Bioorg Med Chem Lett22:7523-9 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-tyrosine kinase 2-beta |
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| Name: | Protein-tyrosine kinase 2-beta |
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| Synonyms: | CADTK | CAK-beta | CAKB | Calcium-dependent tyrosine kinase | Calcium-regulated non-receptor proline-rich tyrosine kinase | Cell adhesion kinase beta | FADK 2 | FAK2_MOUSE | Fak2 | Fak2 | Focal adhesion kinase 2 | Focaladhesion kinase 2 | Proline-rich tyrosine kinase 2 | Ptk2b | Pyk2 | Raftk | Related adhesion focal tyrosine kinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 115790.07 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_885497 |
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| Residue: | 1009 |
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| Sequence: | MSGVSEPLSRVKVGTLRRPEGPPEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK
CTVQTEIQEIITSILLSGRIGPNIQLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC
LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC
LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS
LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDTKPTCLA
EFKQIKSIRCLPLEETQAVLQLGIEGAPQSLSIKTSSLAEAENMADLIDGYCRLQGEHKG
SLIMHAKKDGEKRNSLPQIPTLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGV
AREEVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTQDNKEKFMSEAVIMKN
LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVPTLVLYTLQICKAMAYL
ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR
RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPELCPPVLYTLMTR
CWDYDPSDRPRFTELVCSLSDIYQMEKDIAIEQERNARYRPPKILEPTTFQEPPPKPSRP
KYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMR
EEDFIRPSSREEAQQLWEAEKIKMKQVLERQQKQMVEDSQWLRREERCLDPMVYMNDKSP
LTPEKEAGYTEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYHNVMTLVEAVLELKNKLGQ
LPPEDYVVVVKNVGLNLRKLIGSVDDLLPSLPASSRTEIEGTQKLLNKDLAELINKMKLA
QQNAVTSLSEDCKRQMLTASHTLAVDAKNLLDAVDQAKVVANLAHPPAE
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| BDBM50318872 |
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| n/a |
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| Name | BDBM50318872 |
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| Synonyms: | 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-((pyridin-3-yloxy)methyl)-1H-pyrazol-5-yl)urea | CHEMBL1084269 | PF-4618433 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27N7O2 |
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| Mol. Mass. | 445.5169 |
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| SMILES | Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1cc(COc2cccnc2)n[nH]1)C(C)(C)C |
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| Structure | 
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