| Reaction Details |
|---|
 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-2 |
|---|
| Ligand | BDBM50403018 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_885678 (CHEMBL2211812) |
|---|
| IC50 | 4500000±n/a nM |
|---|
| Citation |  Amagata, T; Xiao, J; Chen, YP; Holsopple, N; Oliver, AG; Gokey, T; Guliaev, AB; Minoura, K Creation of an HDAC-based yeast screening method for evaluation of marine-derived actinomycetes: discovery of streptosetin A. J Nat Prod75:2193-9 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| NAD-dependent protein deacetylase sirtuin-2 |
|---|
| Name: | NAD-dependent protein deacetylase sirtuin-2 |
|---|
| Synonyms: | NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2) |
|---|
| Type: | Hydrolase |
|---|
| Mol. Mass.: | 43172.62 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 389 |
|---|
| Sequence: | MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD
ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE
ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI
MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV
PNPSTSASPKKSPPPAKDEARTTEREKPQ
|
|
|
|---|
| BDBM50403018 |
|---|
| n/a |
|---|
| Name | BDBM50403018 |
|---|
| Synonyms: | CHEMBL2207877 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H25NO5 |
|---|
| Mol. Mass. | 347.4055 |
|---|
| SMILES | CC[C@@H]1CC(=O)[C@@H]2[C@@H](O)C(C)=CC[C@H]2[C@]1(C)C(=O)c1c(O)c[nH]c1O |r,c:10| |
|---|
| Structure | 
|
|---|
Search and Browse
