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Target3-oxo-5-alpha-steroid 4-dehydrogenase 1
LigandBDBM50368782
Substrate/Competitorn/a
Meas. Tech.ChEMBL_205190 (CHEMBL812006)
Ki 4±n/a nM
Citation Abell, ADErhard, KFYen, HYamashita, DSBrandt, MMohammed, HLevy, MAHolt, DA Preparative chiral HPLC separation of all possible stereoisomers of LY191704 and LY266111 and their in vitro inhibition of human types 1 and 2 steroid 5-reductases Bioorg Med Chem Lett4:1365-1368 (1994)    Article
More Info.:Get all data from this article,  Assay Method
 
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Name:3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:Enzyme
Mol. Mass.:29472.80
Organism:Homo sapiens (Human)
Description:P18405
Residue:259
Sequence:
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF
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  Blast E-value cutoff:
BDBM50368782
n/a
NameBDBM50368782
Synonyms:Bexlosteride | CHEMBL24955 | LY-191704
TypeSmall organic molecule
Emp. Form.C14H16ClNO
Mol. Mass.249.736
SMILESCN1[C@@H]2CCc3cc(Cl)ccc3[C@H]2CCC1=O
Structure
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