Reaction Details |
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Target | Neprilysin |
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Ligand | BDBM50403280 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_144628 (CHEMBL752986) |
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IC50 | 3±n/a nM |
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Citation | Robl, JA; Sun, C; Simpkins, LM; Ryono, DE; Barrish, JC; Karanewsky, DS; Asaad, MM; Schaeffer, TR; Trippodo, NC Dual metalloprotease inhibitors. III. utilization of bicyclic and monocyclic diazepinone based mercaptoacetyls Bioorg Med Chem Lett4:2055-2060 (1994) Article |
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More Info.: | Get all data from this article, Assay Method |
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Neprilysin |
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Name: | Neprilysin |
Synonyms: | Atriopeptidase | CALLA | CD_antigen=CD10 | Common acute lymphocytic leukemia antigen | EPN | Enkephalinase | MME | NEP | NEP_HUMAN | Neutral Endopeptidase (NEP) | Neutral endopeptidase | Neutral endopeptidase 24.11 |
Type: | Enzyme |
Mol. Mass.: | 85505.38 |
Organism: | Homo sapiens (Human) |
Description: | P08473 |
Residue: | 750 |
Sequence: | MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
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BDBM50403280 |
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n/a |
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Name | BDBM50403280 |
Synonyms: | CHEMBL65545 |
Type | Small organic molecule |
Emp. Form. | C19H25N3O4S |
Mol. Mass. | 391.484 |
SMILES | OC(=O)[C@@H]1CCCN2CCC[C@H](NC(=O)[C@@H](S)Cc3ccccc3)C(=O)N12 |
Structure |
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