Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM50403350 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_157883 |
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Ki | 53±n/a nM |
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Citation | Thompson, SK; Eppley, AM; Frazee, JS; Darcy, MG; Lum, RT; Tomaszek, TA; Ivanoff, LA; Morris, JF; Sternberg, EJ; Lambert, DM; Fernandez, AV; Petteway, SR; Meek, TD; Metcalf, BW; Gleason, JG Synthesis and antiviral activity of a novel class of HIV-1 protease inhibitors containing a heterocyclic P1-P2 amide bond isostere Bioorg Med Chem Lett4:2441-2446 (1994) Article |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50403350 |
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n/a |
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Name | BDBM50403350 |
Synonyms: | CHEMBL81190 |
Type | Small organic molecule |
Emp. Form. | C31H41N3O4 |
Mol. Mass. | 519.6749 |
SMILES | CCC(C)C(=O)c1cnc([nH]1)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1 |
Structure |
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