Reaction Details |
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Target | Protein c-Fos/Transcription factor Jun |
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Ligand | BDBM50090444 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_92286 (CHEMBL705832) |
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IC50 | 100±n/a nM |
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Citation | Palanki, MS; Erdman, PE; Manning, AM; Ow, A; Ransone, LJ; Spooner, C; Suto, C; Suto, M Novel inhibitors of AP-1 and NF-kappaB mediated gene expression: structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)++ +pyrimidi ne-5-carboxylate. Bioorg Med Chem Lett10:1645-8 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Protein c-Fos/Transcription factor Jun |
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Name: | Protein c-Fos/Transcription factor Jun |
Synonyms: | Proto-oncogene c-JUN/protein c-fos | Transcription factor AP1 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 305353 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Transcription factor Jun |
Synonyms: | AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39 |
Type: | n/a |
Mol. Mass.: | 35683.24 |
Organism: | Homo sapiens (Human) |
Description: | P05412 |
Residue: | 331 |
Sequence: | MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
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Component 2 |
Name: | Protein c-Fos |
Synonyms: | FOS | FOS_HUMAN | G0S7 | Transcription factor AP1 |
Type: | PROTEIN |
Mol. Mass.: | 40679.34 |
Organism: | Homo sapiens (Human) |
Description: | EBI_100167 |
Residue: | 380 |
Sequence: | MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANF
IPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRA
QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ
TEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFT
LPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYA
ADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRK
GSSSNEPSSDSLSSPTLLAL
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BDBM50090444 |
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n/a |
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Name | BDBM50090444 |
Synonyms: | 4-(3-Methyl-2,5-dioxo-2,5-dihydro-pyrrol-1-ylamino)-2-phenyl-pyrimidine-5-carboxylic acid ethyl ester | CHEMBL42952 | ethyl 4-(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)-2-phenylpyrimidine-5-carboxylate |
Type | Small organic molecule |
Emp. Form. | C18H16N4O4 |
Mol. Mass. | 352.344 |
SMILES | CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)-c1ccccc1 |t:16| |
Structure |
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