Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetProtein c-Fos/Transcription factor Jun
LigandBDBM50090420
Substrate/Competitorn/a
Meas. Tech.ChEMBL_92286 (CHEMBL705832)
IC50 200±n/a nM
Citation Palanki, MSErdman, PEManning, AMOw, ARansone, LJSpooner, CSuto, CSuto, M Novel inhibitors of AP-1 and NF-kappaB mediated gene expression: structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)++ +pyrimidi ne-5-carboxylate. Bioorg Med Chem Lett10:1645-8 (2000) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Protein c-Fos/Transcription factor Jun
Name:Protein c-Fos/Transcription factor Jun
Synonyms:Proto-oncogene c-JUN/protein c-fos | Transcription factor AP1
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 305353
Components:This complex has 2 components.
Component 1
Name:Transcription factor Jun
Synonyms:AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Type:n/a
Mol. Mass.:35683.24
Organism:Homo sapiens (Human)
Description:P05412
Residue:331
Sequence:
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Protein c-Fos
Synonyms:FOS | FOS_HUMAN | G0S7 | Transcription factor AP1
Type:PROTEIN
Mol. Mass.:40679.34
Organism:Homo sapiens (Human)
Description:EBI_100167
Residue:380
Sequence:
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANF
IPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRA
QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ
TEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFT
LPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYA
ADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRK
GSSSNEPSSDSLSSPTLLAL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50090420
n/a
NameBDBM50090420
Synonyms:4-(3-Methyl-2,5-dioxo-2,5-dihydro-pyrrol-1-ylamino)-2-(5-methyl-thiophen-2-yl)-pyrimidine-5-carboxylic acid ethyl ester | CHEMBL42650 | ethyl 4-(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)-2-(5-methylthiophen-2-yl)pyrimidine-5-carboxylate
TypeSmall organic molecule
Emp. Form.C17H16N4O4S
Mol. Mass.372.398
SMILESCCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)-c1ccc(C)s1 |t:16|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: