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TargetProto-oncogene c-JUN/protein c-fos
LigandBDBM50090429
Substrate/Competitorn/a
Meas. Tech.ChEMBL_92286
IC50 300±n/a nM
Citation Palanki MSErdman PEManning AMOw ARansone LJSpooner CSuto CSuto M Novel inhibitors of AP-1 and NF-kappaB mediated gene expression: structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)++ +pyrimidi ne-5-carboxylate. Bioorg Med Chem Lett 10:1645-8 (2000) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Proto-oncogene c-JUN/protein c-fos
Name:Proto-oncogene c-JUN/protein c-fos
Synonyms:Transcription factor AP1
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 305353
Components:This complex has 2 components.
Component 1
Name:Transcription factor AP-1
Synonyms:AP1 | Activator protein 1 | JUN | Proto-oncogene c-JUN | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Type:n/a
Mol. Mass.:35683.24
Organism:Homo sapiens (Human)
Description:P05412
Residue:331
Sequence:
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
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Component 2
Name:Transcription factor AP1
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:40679.34
Organism:Homo sapiens (Human)
Description:EBI_100167
Residue:380
Sequence:
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANF
IPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRA
QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ
TEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFT
LPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYA
ADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRK
GSSSNEPSSDSLSSPTLLAL
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BDBM50090429
n/a
NameBDBM50090429
Synonyms:2-(3,5-Dichloro-phenyl)-4-(3-methyl-2,5-dioxo-2,5-dihydro-pyrrol-1-ylamino)-pyrimidine-5-carboxylic acid ethyl ester | CHEMBL296202 | ethyl 2-(3,5-dichlorophenyl)-4-(3-methyl-2,5-dioxo-2H-pyrrol-1(5H)-ylamino)pyrimidine-5-carboxylate
TypeSmall organic molecule
Emp. Form.C18H14Cl2N4O4
Mol. Mass.421.234
SMILESCCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)-c1cc(Cl)cc(Cl)c1 |t:16|
Structure
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