Reaction Details |
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Target | Protein c-Fos/Transcription factor Jun |
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Ligand | BDBM50090435 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_92286 (CHEMBL705832) |
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IC50 | 300±n/a nM |
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Citation | Palanki, MS; Erdman, PE; Manning, AM; Ow, A; Ransone, LJ; Spooner, C; Suto, C; Suto, M Novel inhibitors of AP-1 and NF-kappaB mediated gene expression: structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)++ +pyrimidi ne-5-carboxylate. Bioorg Med Chem Lett10:1645-8 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Protein c-Fos/Transcription factor Jun |
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Name: | Protein c-Fos/Transcription factor Jun |
Synonyms: | Proto-oncogene c-JUN/protein c-fos | Transcription factor AP1 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 305353 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Transcription factor Jun |
Synonyms: | AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39 |
Type: | n/a |
Mol. Mass.: | 35683.24 |
Organism: | Homo sapiens (Human) |
Description: | P05412 |
Residue: | 331 |
Sequence: | MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
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Component 2 |
Name: | Protein c-Fos |
Synonyms: | FOS | FOS_HUMAN | G0S7 | Transcription factor AP1 |
Type: | PROTEIN |
Mol. Mass.: | 40679.34 |
Organism: | Homo sapiens (Human) |
Description: | EBI_100167 |
Residue: | 380 |
Sequence: | MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANF
IPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRA
QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ
TEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFT
LPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYA
ADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRK
GSSSNEPSSDSLSSPTLLAL
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BDBM50090435 |
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n/a |
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Name | BDBM50090435 |
Synonyms: | 3-Methyl-1-[5-(3-methyl-isoxazol-5-yl)-2-thiophen-2-yl-pyrimidin-4-ylamino]-pyrrole-2,5-dione | 3-methyl-1-(5-(3-methylisoxazol-5-yl)-2-(thiophen-2-yl)pyrimidin-4-ylamino)-1H-pyrrole-2,5-dione | CHEMBL45261 |
Type | Small organic molecule |
Emp. Form. | C17H13N5O3S |
Mol. Mass. | 367.382 |
SMILES | CC1=CC(=O)N(Nc2nc(ncc2-c2cc(C)no2)-c2cccs2)C1=O |t:1| |
Structure |
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