| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acyl carrier protein,/NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial |
|---|
| Ligand | BDBM50094728 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_141738 (CHEMBL749250) |
|---|
| IC50 | 0.600000±n/a nM |
|---|
| Citation |  Tormo, JR; Estornell, E; Gallardo, T; González, MC; Cavé, A; Granell, S; Cortes, D; Zafra-Polo, MC Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I. Bioorg Med Chem Lett11:681-4 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acyl carrier protein,/NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial |
|---|
| Name: | Acyl carrier protein,/NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial |
|---|
| Synonyms: | Mitochondrial complex I; NADH oxidoreductase |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of EBI is 141738 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial |
|---|
| Synonyms: | CI-51kD | Complex I-51kD | NADH dehydrogenase flavoprotein 1 | NADH-ubiquinone oxidoreductase 51 kDa subunit | NDUFV1 | NDUV1_BOVIN | UQOR1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50659.85 |
|---|
| Organism: | Bos taurus |
|---|
| Description: | EBI_100771 |
|---|
| Residue: | 464 |
|---|
| Sequence: | MLAARRLLGGSLPARVSVRFSGDTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGAQSRG
DWYKTKEILLKGPDWILGEVKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEG
EPGTCKDREIIRHDPHKLVEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAG
LIGKNACGSGYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPT
TVANVETVAVSPTICRRGGAWFASFGRERNSGTKLFNISGHVNNPCTVEEEMSVPLKELI
EKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALIQAQTGLGTAAVIVMDRS
TDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVRGDARPAEIDSLWEISKQIE
GHTICALGDGAAWPVQGLIRHFRPELEERMQQFAQQHQARQAAF
|
|
|
|---|
| Component 2 |
| Name: | Acyl carrier protein, mitochondrial |
|---|
| Synonyms: | ACP | ACPM_BOVIN | CI-SDAP | NADH-ubiquinone oxidoreductase 9.6 kDa subunit | NDUFAB1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 17397.64 |
|---|
| Organism: | Bos taurus |
|---|
| Description: | ChEMBL_469770 |
|---|
| Residue: | 156 |
|---|
| Sequence: | MAVRVLCACVRRLPTAFAPLPRLPTLAAARPLSTTLFAAETRTRPGAPLPALVLAQVPGR
VTQLCRQYSDAPPLTLEGIKDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIM
AMEDEFGFEIPDIDAEKLMCPQEIVDYIADKKDVYE
|
|
|
|---|
| BDBM50094728 |
|---|
| n/a |
|---|
| Name | BDBM50094728 |
|---|
| Synonyms: | (S)-3-((2R,13R)-2,13-dihydroxy-13-((2S,2'S,5R,5'R)-5'-((S)-1-hydroxyundecyl)octahydro-2,2'-bifuran-5-yl)tridecyl)-5-methylfuran-2(5H)-one | (S)-3-{(2R,13R)-2,13-Dihydroxy-13-[(2S,5R,2'S,5'R)-5'-((S)-1-hydroxy-undecyl)-octahydro-[2,2']bifuranyl-5-yl]-tridecyl}-5-methyl-5H-furan-2-one | 3-{2,13-Dihydroxy-13-[5'-(1-hydroxy-undecyl)-octahydro-[2,2']bifuranyl-5-yl]-tridecyl}-5-methyl-5H-furan-2-one(Rolliniastatin-1) | CHEMBL142918 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C37H66O7 |
|---|
| Mol. Mass. | 622.9157 |
|---|
| SMILES | CCCCCCCCCC[C@H](O)[C@H]1CC[C@H](O1)[C@@H]1CC[C@@H](O1)[C@H](O)CCCCCCCCCC[C@@H](O)CC1=C[C@H](C)OC1=O |r,t:39| |
|---|
| Structure | 
|
|---|
Search and Browse
