| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl carrier protein,/NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial |
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| Ligand | BDBM50403906 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_141738 (CHEMBL749250) |
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| IC50 | 2.5±n/a nM |
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| Citation |  Tormo, JR; Estornell, E; Gallardo, T; González, MC; Cavé, A; Granell, S; Cortes, D; Zafra-Polo, MC Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I. Bioorg Med Chem Lett11:681-4 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl carrier protein,/NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial |
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| Name: | Acyl carrier protein,/NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial |
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| Synonyms: | Mitochondrial complex I; NADH oxidoreductase |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 141738 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial |
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| Synonyms: | CI-51kD | Complex I-51kD | NADH dehydrogenase flavoprotein 1 | NADH-ubiquinone oxidoreductase 51 kDa subunit | NDUFV1 | NDUV1_BOVIN | UQOR1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50659.85 |
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| Organism: | Bos taurus |
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| Description: | EBI_100771 |
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| Residue: | 464 |
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| Sequence: | MLAARRLLGGSLPARVSVRFSGDTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGAQSRG
DWYKTKEILLKGPDWILGEVKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEG
EPGTCKDREIIRHDPHKLVEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAG
LIGKNACGSGYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPT
TVANVETVAVSPTICRRGGAWFASFGRERNSGTKLFNISGHVNNPCTVEEEMSVPLKELI
EKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALIQAQTGLGTAAVIVMDRS
TDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVRGDARPAEIDSLWEISKQIE
GHTICALGDGAAWPVQGLIRHFRPELEERMQQFAQQHQARQAAF
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| Component 2 |
| Name: | Acyl carrier protein, mitochondrial |
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| Synonyms: | ACP | ACPM_BOVIN | CI-SDAP | NADH-ubiquinone oxidoreductase 9.6 kDa subunit | NDUFAB1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 17397.64 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_469770 |
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| Residue: | 156 |
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| Sequence: | MAVRVLCACVRRLPTAFAPLPRLPTLAAARPLSTTLFAAETRTRPGAPLPALVLAQVPGR
VTQLCRQYSDAPPLTLEGIKDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIM
AMEDEFGFEIPDIDAEKLMCPQEIVDYIADKKDVYE
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| BDBM50403906 |
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| n/a |
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| Name | BDBM50403906 |
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| Synonyms: | CHEMBL162504 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H68O8 |
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| Mol. Mass. | 640.931 |
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| SMILES | CCCCCCCCCC[C@@H](O)[C@@H]1CC[C@H](O1)[C@@H](O)CC[C@H](O)[C@@H]1CC[C@@H](CCCCCCC[C@H]2CC(CC(C)O)C(=O)O2)O1 |
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| Structure | 
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