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TargetATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial
LigandBDBM50404294
Substrate/Competitorn/a
Meas. Tech.ChEMBL_65922 (CHEMBL678317)
IC50 2490±n/a nM
Citation Atwal, KSAhmad, SDing, CZStein, PDLloyd, JHamann, LGGreen, DWFerrara, FNWang, PRogers, WLDoweyko, LMMiller, AVBisaha, SNSchmidt, JBLi, LYost, KJLan, HJMadsen, CS N-[1-Aryl-2-(1-imidazolo)ethyl]-guanidine derivatives as potent inhibitors of the bovine mitochondrial F1F0 ATP hydrolase. Bioorg Med Chem Lett14:1027-30 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
ATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial
Name:ATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial
Synonyms:Mitochondrial complex V; ATP synthase
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 65924
Components:This complex has 4 components.
Component 1
Name:ATP synthase subunit epsilon, mitochondrial
Synonyms:ATP5E | ATP5E_BOVIN | ATP5F1E | ATPase subunit epsilon
Type:PROTEIN
Mol. Mass.:5790.87
Organism:Bos taurus
Description:EBI_100264
Residue:51
Sequence:
MVAYWRQAGLSYIRYSQICAKAVRDALKTEFKANAMKTSGSTIKIVKVKKE
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Component 2
Name:ATP synthase subunit beta, mitochondrial
Synonyms:ATP5B | ATP5F1B | ATPB_BOVIN
Type:PROTEIN
Mol. Mass.:56271.25
Organism:Bos taurus
Description:EBI_100264
Residue:528
Sequence:
MLGLVGRVVAASASGALRGLSPSAPLPQAQLLLRAAPAALQPARDYAAQASPSPKAGATT
GRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTVRTIAMDGTEGLV
RGQKVLDSGAPIRIPVGPETLGRIMNVIGEPIDERGPIKTKQFAAIHAEAPEFVEMSVEQ
EILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERT
REGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQD
VLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAI
YVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDV
ARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHLGK
LVPLKETIKGFQQILAGEYDHLPEQAFYMVGPIEEAVAKADKLAEEHS
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Component 3
Name:ATP synthase subunit gamma, mitochondrial
Synonyms:ATP5C | ATP5C1 | ATP5F1C | ATPG_BOVIN | F-ATPase gamma subunit
Type:PROTEIN
Mol. Mass.:33081.70
Organism:Bos taurus
Description:ChEMBL_65923
Residue:298
Sequence:
MFSRAGVAGLSAWTVQPQWIQVRNMATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAE
RELKPARVYGVGSLALYEKADIKTPEDKKKHLIIGVSSDRGLCGAIHSSVAKQMKSEAAN
LAAAGKEVKIIGVGDKIRSILHRTHSDQFLVTFKEVGRRPPTFGDASVIALELLNSGYEF
DEGSIIFNRFRSVISYKTEEKPIFSLDTISSAESMSIYDDIDADVLRNYQEYSLANIIYY
SLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAALD
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Component 4
Name:ATP synthase subunit delta, mitochondrial
Synonyms:ATP5D | ATP5F1D | ATPD_BOVIN | F-ATPase delta subunit
Type:PROTEIN
Mol. Mass.:17608.84
Organism:Bos taurus
Description:EBI_100264
Residue:168
Sequence:
MLPSALLRRPGLGRLVRQVRLYAEAAAAQAPAAGPGQMSFTFASPTQVFFNSANVRQVDV
PTQTGAFGILAAHVPTLQVLRPGLVVVHAEDGTTSKYFVSSGSVTVNADSSVQLLAEEAV
TLDMLDLGAAKANLEKAQSELLGAADEATRAEIQIRIEANEALVKALE
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BDBM50404294
n/a
NameBDBM50404294
Synonyms:CHEMBL269307
TypeSmall organic molecule
Emp. Form.C19H14Cl4N6
Mol. Mass.468.167
SMILESClc1ccc(C(Cn2ccnc2)NC(Nc2cccc(Cl)c2Cl)=NC#N)c(Cl)c1 |w:23.25|
Structure
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