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TargetMalate dehydrogenase, mitochondrial
LigandBDBM50404717
Substrate/Competitorn/a
Meas. Tech.ChEMBL_123822 (CHEMBL733653)
IC50 4786.3±n/a nM
Citation Coats, EAShah, KJMilstein, SRGenther, CSNene, DMRoesener, JSchmidt, JPleiss, MWagner, EBaker, JK 4-hydroxyquinoline-3-carboxylic acids as inhibitors of cell respiration. 2. Quantitative structure-activity relationship of dehydrogenase enzyme and Ehrlich ascites tumor cell inhibitions. J Med Chem25:57-63 (1982) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Malate dehydrogenase, mitochondrial
Name:Malate dehydrogenase, mitochondrial
Synonyms:MDH2 | MDHM_PIG | Malate dehydrogenase mitochondrial
Type:Oxidoreductase; homodimer
Mol. Mass.:35493.48
Organism:Sus scrofa (pig)
Description:Porcine heart mitochondria.
Residue:337
Sequence:
MLSALARPAGAALRRSFSTSQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHT
PGVAADLSHIETRATVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIV
ATLTAACAQHCPDAMICIISNPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANAFV
AELKGLDPARVSVPVIGGHAGKTIIPLISQCTPKVDFPQDQLSTLTGRIQEAGTEVVKAK
AGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETDCPYFSTPLLLGKKGIEK
NLGIGKISPFEEKMIAEAIPELKASIKKGEEFVKNMK
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  Blast E-value cutoff:
BDBM50404717
n/a
NameBDBM50404717
Synonyms:CHEMBL157654
TypeSmall organic molecule
Emp. Form.C17H11Cl2NO4
Mol. Mass.364.18
SMILESOC(=O)c1cnc2cc(OCc3ccc(Cl)c(Cl)c3)ccc2c1O
Structure
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