| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H2 receptor |
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| Ligand | BDBM22893 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_84894 |
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| Ki | 501±n/a nM |
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| Citation |  Lumma, WC; Anderson, PS; Baldwin, JJ; Bolhofer, WA; Habecker, CN; Hirshfield, JM; Pietruszkiewicz, AM; Randall, WC; Torchiana, ML; Britcher, SF; Clineschmidt, BV; Denny, GH; Hirschmann, R; Hoffman, MJ; Phillips, BT; Streeter, KB Inhibitors of gastric acid secretion: 3,4-diamino-1,2,5-thiadiazole 1-oxides and 1,1-dioxides as urea equivalents in a series of histamine H2-receptor antagonists. J Med Chem25:207-10 (1982) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H2 receptor |
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| Name: | Histamine H2 receptor |
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| Synonyms: | Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_CAVPO | Histamine H2-Gs alpha S |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40567.22 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | For the H2 receptor-binding assays, guinea pig striatum was used. |
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| Residue: | 359 |
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| Sequence: | MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSL
AVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
TDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVM
GAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYH
QLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
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| BDBM22893 |
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| n/a |
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| Name | BDBM22893 |
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| Synonyms: | CHEMBL512 | Ranitidine | ZANTAC | dimethyl[(5-{[(2-{[(E)-1-(methylamino)-2-nitroethenyl]amino}ethyl)sulfanyl]methyl}furan-2-yl)methyl]amine |
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| Type | Small organic molecule |
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| Emp. Form. | C13H22N4O3S |
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| Mol. Mass. | 314.404 |
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| SMILES | CN\C([CH-][N+]([O-])=O)=[NH+]/CCSCc1ccc(CN(C)C)o1 |
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| Structure | 
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