Reaction Details |
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Target | Histamine H2 receptor |
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Ligand | BDBM22568 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_84892 |
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Ki | 32±n/a nM |
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Citation | Hoffman, JM; Pietruszkiewicz, AM; Habecker, CN; Phillips, BT; Bolhofer, WA; Cragoe, EJ; Torchiana, ML; Lumma, WC; Baldwin, JJ Conformational requirements for histamine H2-receptor inhibitors: a structure-activity study of phenylene analogues related to cimetidine and tiotidine. J Med Chem26:140-4 (1983) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H2 receptor |
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Name: | Histamine H2 receptor |
Synonyms: | Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_CAVPO | Histamine H2-Gs alpha S |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40567.22 |
Organism: | Cavia porcellus (domestic guinea pig) |
Description: | For the H2 receptor-binding assays, guinea pig striatum was used. |
Residue: | 359 |
Sequence: | MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSL
AVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
TDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVM
GAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYH
QLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
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BDBM22568 |
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n/a |
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Name | BDBM22568 |
Synonyms: | 1-cyano-3-{2-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]ethyl}-2-methylguanidine | [3H]tiotidine | tiotidine |
Type | Small organic molecule |
Emp. Form. | C10H16N8S2 |
Mol. Mass. | 312.418 |
SMILES | [#6]-[#7]-[#6](-[#7]C#N)=[#7]-[#6]-[#6]-[#16]-[#6]-c1csc(\[#7]=[#6](\[#7])-[#7])n1 |w:6.6| |
Structure |
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