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TargetDihydrofolate reductase
LigandBDBM50405068
Substrate/Competitorn/a
Meas. Tech.ChEBML_55071
Ki 2042±n/a nM
Citation Hansch CHathaway BAGuo ZRSelassie CDDietrich SWBlaney JMLangridge RVolz KWKaufman BT Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s. J Med Chem 27:129-43 (1984) [PubMed]
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Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:18437.08
Organism:Lactobacillus casei
Description:ChEMBL_1357878
Residue:163
Sequence:
MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN
VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA
GSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
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BDBM50405068
n/a
NameBDBM50405068
Synonyms:CHEMBL34274
TypeSmall organic molecule
Emp. Form.C18H27N5O
Mol. Mass.329.4399
SMILESCC1(C)N=C(N)N=C(N)N1c1cccc(COC2CCCCC2)c1 |t:3,6|
Structure
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